9-Hydroxy-1,2,3,4,5,6-hexahydro-1,5-methano-3-benzazocine derivatives as analgesics
- 1 February 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (2) , 310-312
- https://doi.org/10.1021/jm00212a027
Abstract
Three 1,3-dimethyl-9-hydroxy-1,2,3,4,5,6-hexahydro-1,5-methano-3-benzazocine derivatives (7-9) were synthesized and tested as analgesics. The synthesis of these compounds involved conversion of 1-methyl-7-methoxy-.beta.-tetralone (1) by Mannich reaction with MeNH2 and HCHO to give the 11-ketone 2, from which 7, 8 and 9, respectively, were obtained. These compounds have analgesic activity, and 7 was comparable to codeine in mice.This publication has 1 reference indexed in Scilit:
- 10-Hydroxy-4-methyl-2,3,4,5,6,7-hexahydro-1,6-methano-1H-4-benzazonine derivatives (homobenzomorphans) as analgesicsJournal of Medicinal Chemistry, 1976