Automated Platelet-Sizing Parameters on a Normal Population

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Abstract
The quantitation of platelets in peripheral blood is a well-recognized tool. However, other platelet parameters that recently have become available on a routine basis with the introduction of automated cell sizers may become increasingly important in evaluating the integrity of the thrombocytic function. These parameters include mean platelet volume (MPV) and platelet-crit (PCT). This study established reliable reference ranges for these platelet parameters while taking into consideration the effects of age and sex in a study population of 447 normal persons. There was an inverse, nonlinear relationship between MPV and platelet count, with no statistical difference (P > 0.05) seen between males and females. Platelet-crit showed no variation with respect to age or sex, however, a direct, linear relationship was suggested between PCT and platelet count. These relationships provide a better understanding of these platelet parameters and may contribute to their use as helpful diagnostic aids.

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