Research in Cystic Fibrosis

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Abstract
(Third of Three Parts)Autonomic Nervous SystemMost of the clinical features of cystic fibrosis are due to malfunction of exocrine glands, which are intimately associated with autonomic nerve fibers. Therefore, dysfunction of this system has always been an attractive explanation for this generalized exocrinopathy. However, the studies performed in the past have resulted in either negative or controversial findings.1 More recently, in 1973, a careful ultrastructure and histochemical study of autonomic nerve fibers in labial salivary glands from patients with cystic fibrosis failed to identify any differences from normal.143 Conversely, experimental studies using animal models have been more fruitful. . . .