IMPAIRED INDUCTION OF TYPE-II INTERFERON IN TUMOR-BEARING MICE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 40  (3) , 873-876
Abstract
The response of mice to type II interferon inducers such as purified protein derivative of tuberculin or OK-432 was significantly impaired after the implantation of tumor cells or the injection of cell-free tumor ascitic fluids. Complete inhibition of type II interferon induction occurred in 3-5 days. This inhibitory effect persisted until the death of mice implanted with tumors or for 7 days after i.p. injection of 0.2 ml of tumor ascitic fluid. The inhibitory activity was seen even with 0.2 ml of the 10,000-fold dilution of the fluid and with its filtrate passed through a Diaflo UM-10 membrane (> 10,000-dalton exclusion). Such tumor ascitic fluids did not affect the induction of type I interferon in mice by polyriboinosinic polyribocytidylic acid or tilorone-HCl. Adjuvant-induced nontumorous ascitic fluid had no inhibitory activity. The in vivo induction of type II interferon apparently is specifically impaired by tumor-mediated factor(s) with MW < 10,000.

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