Studies of the Selective O-Alkylation and Dealkylation of Flavonoids. V. The Synthesis of 5,6-Dihydroxy-3,4′,8-trimethoxyflavone and a Revised Structure for the Flavone from Conyza stricta

Abstract
5,6-Dihydroxy-3,4′,8-trimethoxyflavone, which was the proposed structure of the pigment occuring in Conyza stricta, was synthesized from 2,3,5,6-tetramethoxyacetophenone in six steps. The natural pigment was identical not with the synthesized flavone, but with 5,7-dihydroxy-3,4′,8-trimethoxyflavone, an isomer of the former.

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