Detection of common motifs in RNA secondary structures
- 1 January 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 17 (12) , 4829-4845
- https://doi.org/10.1093/nar/17.12.4829
Abstract
We describe a noval computerized system for comparison of RNA secondary structures and demonstrate its use for experimental studies. The system is able to screen a very large number of structures, to cluster similar structures and to detect specific structural motifs. In particular, the system is useful for detecting mutations with specific structural effects among all possible point mutations, and for predicting compensatory mutations that will restore the wild type structure. The algorithms are independent of the following rules that are used to generate the secondary structures.This publication has 26 references indexed in Scilit:
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