Rilmenidine-Induced Hypotension in Conscious Rabbits Involves Imidazoline-Preferring sReceptors

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Abstract
The relative contributions of imidazoline-preferring receptors (IPR) and alpha 2-adrenoceptors to hypotensive and bradycardic effects of intracisternal (i.c.) rilmenidine were investigated in conscious rabbits. We compared the antagonist potencies of two alpha 2-adrenoceptor antagonists, 2-methoxy-idazoxan (0.001-10 micrograms/kg i.c.), which has very low affinity for IPR, and idazoxan (0.003-30 micrograms/kg i.c.), which has high affinity for blocking IPR. We also compared the i.c. effects of the antagonists on responses to alpha-methyldopa (alpha-MD), a drug with centrally acting alpha 2-adrenoceptor agonist metabolites that have no affinity for IPR. Rilmenidine (22 micrograms/kg i.c.) and alpha-MD (400 micrograms/kg i.c.) produced similar decreases in mean arterial pressure (MAP) (delta MAP = -23 +/- 2 and -24 +/- 2%, respectively) and in heart rate (HR) (delta HR = -11 +/- 1 and -9 +/- 2%, respectively, n = 30). The hypotension and bradycardia produced by alpha-MD and rilmenidine were completely reversed by 2-methoxy-idazoxan, but 2-methoxy-idazoxan was 16 and 9 times more potent at restoring MAP and HR, respectively, after alpha-MD than after rilmenidine. In contrast, idazoxan was more potent in reversing the hypotension elicited by i.c. injections of rilmenidine than that elicited by alpha-MD. Idazoxan, however, had no effect on rilmenidine-induced bradycardia, but did dose-dependently reverse the decrease in HR produced by alpha-MD. In separate experiments, we observed that the doses of each antagonist drug in themselves did not modify MAP nor HR significantly, but a 10-fold higher dose of idazoxan (300 micrograms/kg) caused immediate although brief hypertension and tachycardia.(ABSTRACT TRUNCATED AT 250 WORDS)

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