INVITRO CHARACTERISTICS ON HUMAN-LYMPHOCYTE FUNCTIONS OF A NEW IMMUNOMODULATORY AGENT, A CYCLIC PEPTIDE, CYCLOMUNINE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 42  (2) , 315-323
Abstract
Cyclomunine, a cyclic peptide extracted from Fusarium equiseti, inhibits responses of human lymphocytes to mitogens, soluble antigens and allogeneic cells and the proliferation of [human tumor] lymphoblastoid cell lines. Cyclomunine has little effect on small lymphocytes but acts on lymphoblasts. It has no effect on fibroblasts and myeloid cells. Cyclomunine partially inhibits the generation of suppressor cells induced by Con [concanavalin] A and the generation of cytotoxic T cells in a mixed lymphocyte culture and totally inhibits the in vitro synthesis of Ig by PBL [peripheral blood lymphocytes]. Cyclomunine merits consideration as a new in vitro anti-lymphoblastic agent.