We report on the fabrication of a new class of trilayer epitaxial thin film devices based on the doped perovskite manganates La–Ca–Mn–O and La–Sr–Mn–O. We show that large resistance changes, up to a factor of 2, can be induced by a moderate applied magnetic field below 200 Oe in these trilayers supporting current‐perpendicular‐to‐plane transport. These results show that low‐field spin‐dependent transport in manganates can be accomplished, the magnitude of which is suitable for magnetoresistive field sensors.