Motor Neuron Disease following Poliomyelitis

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Abstract
Five cases of late motor neuron degeneration following poliomyelitis are presented. CPK [creatine phosphokinase], CSF, EMG [electromyography] and spine radiology were studied. In all cases, muscle biopsy evidenced neurogenic alterations in previously affected limbs and in newly affected ones. Mitochondrial abnormalities were found in 1 case. The findings are discussed with particular regard to the pathogenesis of the disease. The case with abnormal mitochondria is stressed for the possible relationship of this pathology with systemic degenerative diseases.