A reexamination of the potential comedogenicity of sulfur

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Abstract
Studies were done by 2 different investigators in 2 separate institutions with groups of 12 and 40 subjects, respectively. Biopsy specimens were obtained from the occluded test sites before and after a 6 wk period of treatment. Each subject received a patch test of 5% S in either an octoxynol 9 (Triton X-100) or a carbomer 934P (Carbopol 934P) vehicle and 1 of 2 controls consisting of the Triton X-100 vehicle or a dry patch test. No trend or correlation was noted between the presence or absence of S in the formulation and the appearance of comedones. The Triton X-100 vehicle itself appeared to be comedogenic under the experimental conditions.

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