Effect of Dietary Selenium and Autoxidized Lipids on the Glutathione Peroxidase System of Gastrointestinal Tract and other Tissues in the Rat

Publisher Website
Google Scholar
Abstract
The effect of dietary selenium on the detoxification of dietary peroxides via the glutathione peroxidase system was studied. Rats were fed Torula yeast-based selenium-deficient diets with either 15% fresh tocopherol-stripped corn oil or 15% autoxidized corn oil with a peroxide value of 692 mEq/kg. Rats fed these two diets were further divided into groups that were fed either 0 or 2 ppm selenium as selenomethionine. Body weight gain of the two groups of rats fed the autoxidized oil was significantly lower than that of the two groups fed fresh corn oil. The specific activity of glutathione peroxidase in various regions of the gastrointestinal tract, liver, blood, and adipose from selenium-supplemented rats was significantly higher than in these tissues from the nonsupplemented rats. In the rats not supplemented with selenium, glutathione peroxidase activity was significantly increased in the group fed autoxidized corn oil; increased activity was not observed in tissues of selenium-supplemented rats fed peroxides. With few exceptions, glutathione reductase activity was the same in tissues from each of the four dietary groups. Significantly more peroxide accumulated in the adipose of the peroxide-fed rats not supplemented with selenium than in the adipose of the other three groups.

This publication has 36 references indexed in Scilit: