Drug-Related Lupus

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Abstract
Systemic lupus erythematosus is one of the connective-tissue diseases whose specific cause or causes remain undetermined. However, it is known that drugs and other agents can produce a lupuslike syndrome: drug-related lupus. The first case of probable drug-related lupus was described by Hoffman in 1945 and implicated the antibiotic sulfadiazine.1 The first definite relation between drug and syndrome was reported by Morrow et al. in 1953 with the use of hydralazine.2 Procainamide-related lupus was first reported in 1962,3 and a number of confirming studies quickly followed. Since the 1970s, at least 46 more drugs and agents have been reported to . . .