SENSITIVITY TO CHEMOTHERAPEUTIC AND IMMUNOMODULATING AGENTS OF 2 MOUSE LYMPHOMAS AND OF A MACROPHAGE TUMOR

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 39  (10) , 3964-3967
Abstract
The effect of treatment with 15 chemotherapeutic and 10 immunomodulating agents on the growth of T[thymus-derived]-cell lymphoma EL-4, macrophage tumor J774, and B[bone marrow-derived]-cell lymphoma 70Z/2 of the mouse was studied using the prolongation of median survival time of tumor-bearing hosts as an index of therapeutic effectiveness. The survival time of mice bearing 70Z/2 was prolonged more than 100% by single-agent therapy with actinomycin D, cyclophosphamide, 6-mercaptopurine, mitomycin C and vinblastine; a similar response of J774 was produced by therapy with adriamycin, cyclophosphamide or 6-mercaptopurine. No chemotherapeutic agent prolonged the median survival time of mice bearing EL-4 by 100% or more. Of the immunomodulating agents, mycobacterial preparations (BCG or interphase material), Corynebacterium parvum [Propionibacterium acnes] and polyinosinic-polycytidylic acid moderately prolonged the survival time of mice bearing J774 or 70Z/2; the EL-4 lymphoma was refractory to all 10 immunomodulating agents.