Congophilic angiopathy of the brain: a clinical and pathological report on two siblings.
- 1 May 1982
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 45 (5) , 396-408
- https://doi.org/10.1136/jnnp.45.5.396
Abstract
Clinical and histological accounts are given of a sister and brother, dying aged 61 and 56 yr, respectively, after illnesses lasting 5-6 yr marked by a progressive mental and physical disability. The family history suggested transmission by a dominant gene. The histological findings were of a very severe congophilic angiopathy confined to the brain, spinal cord and leptomeninges and giving rise to multiple hemorrhages and softenings. There were, in addition, abundant amyloid-containing plaques of various forms, found principally in the hippocampus and cerebellar cortex. The cases are compared with similar cases in the literature, and reasons given for regarding this condition as a separate entity rather than a variant of Alzheimer''s disease.This publication has 26 references indexed in Scilit:
- Parkinson disease, dementia, and alzheimer disease: Clinicopathological correlationsAnnals of Neurology, 1980
- Congophilic microangiopathy in the pathogenesis of Alzheimer's syndrome (presenile dementia)Medical Hypotheses, 1979
- Cerebral amyloid angiopathyNeurology, 1979
- Fatal Massive Intracerebral Hemorrhage Complicating Cerebral Amyloid AngiopathyArchives of Neurology, 1978
- The incidence of cerebral amyloid angiopathy in Alzheimer's diseaseNeurology, 1975
- HEREDITARY CEREBRAL HEMORRHAGE WITH AMYLOIDOSISBrain, 1972
- AN UNUSUAL TYPE OF PRE-SENILE DEMENTIA (ATYPICAL ALZHEIMER'S DISEASE WITH AMYLOID VASCULAR CHANGE)Brain, 1954
- Un type particulier d'angiopathie sénile du système nerveux central: l'angiopathie congophile. Topographie et fréquence; pp. 219–237European Neurology, 1954
- A FORM OF FAMILIAL PRESENILE DEMENTIA WITH SPASTIC PARALYSISBrain, 1944
- A FORM OF FAMILIAL PRESENILE DEMENTIA WITH SPASTIC PARALYSISBrain, 1940