Mutagenicity Arising from Boiled Rice on Treatment with Nitrous Acid

Open Access

1 November 1989

journal article
research article
Published by Wiley in Japanese Journal of Cancer Research

Vol. 80 (11) , 1021-1023
https://doi.org/10.1111/j.1349-7006.1989.tb02252.x

Abstract

When an aqueous homogenate of boiled rice was treated with nitrous acid at pH 3, direct‐acting mutagens were formed. The presence of the mutagens was demonstrated by isolating the mutagenic fractions through blue‐rayon adsorption, a method used to extract polycyclic compounds, and subsequent high‐performance liquid chromatography (HPLC). The mutagens were active in Salmonella typhimurium TA100 and TA98 without metabolic activation. Several different mutagens were formed, as judged from the HPLC profile.

Keywords

This publication has 12 references indexed in Scilit:

Mutagenicities of indole and 30 derivatives after nitrite treatment
Mutation Research/Genetic Toxicology, 1986
The nitrosation of alcohol-induced metabolites produces mutagenic substances
Mutation Research/Genetic Toxicology, 1985
Appearance of direct-acting mutagenicity of various foodstuffs produced in Japan and Southeast Asia on nitrite treatment
Mutation Research/Genetic Toxicology, 1985
A mutagen precursor in Chinese cabbage, indole-3-acetonitrile, which becomes mutagenic on nitrite treatment
Mutation Research Letters, 1985
The basis of the insensitivity of Salmonella typhimurium strain TA98/1,8-DNP6 to the mutagenic action of nitroarenes
Mutation Research Letters, 1983
Adsorption of mutagens to cotton bearing covalently bound trisulfo-copper-phthalocyanine
Mutation Research Letters, 1983
A cautionary note on the use of nitroreductase-deficient strains of Salmonella typhimurium for the detection of nitroarenes as mutagens in complex mixtures including diesel exhausts
Mutation Research Letters, 1981
Mutagenicities of N-nitrosamines on salmonella
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1977
The effect of nitrate intake on nitrite formation in human saliva
Food and Cosmetics Toxicology, 1976
Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test
Mutation Research/Environmental Mutagenesis and Related Subjects, 1975