In Vivo Growth and Antigenic Properties of a Rat Sarcoma Induced by Moloney Sarcoma Virus2

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Abstract
The growth and antigenic properties of a BN Moloney sarcoma (MST) were examined in syngeneic (BN) and allogeneic (lewis) rats. In BN rats, MST doses of 5 × 106 cells and higher were invariably fatal, and tumor growth was most rapid when MST was injected intraperitoneally. lewis rats were completely resistant to MST doses up to 5×l07 cells. lewis rats produced a greater cell-mediated cytotoxicity response than did BN rats, directed chiefly to AgB antigens, and they yielded less anti-gs-1 antibody. Growth of MST in BN rats was inhibited by immune spleen cells and MP lectin, was not affected by phytohemagglutinin or concanavalin A, and was enhanced by immune serum. Lewis rats, hyperimmunized with MST, produced antibody to alloantigens and to tumorspecific and virus-related antigens. Antitumor antibody could be eluted from growing solid tumors of either host. Studies with enriched radiolabeled anti-AgB antibody showed that MST cells carried about 50% of the alloantigen content of normal BN cells, but that amount was sufficient to provoke a brisk immune response in lewis rats.

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