COMBINING SUMMARIES OF BINARY OUTCOMES WITH THOSE OF CONTINUOUS OUTCOMES IN A META-ANALYSIS

2 February 1999

journal article
review article
Published by Taylor & Francis in Journal of Biopharmaceutical Statistics

Vol. 9 (1) , 1-16
https://doi.org/10.1081/bip-100100997

Abstract

We present a methodology for combining trials some of which report continuous outcome measures and others binary outcomes created by a dichotomy of the continuous measurement. This was motivated by a series of controlled clinical trials investigating the effect of prophylactic use of oxytocics on postpartum blood loss during labor. Data were available in the form of summary statistics from published papers. The log-odds ratio is used as a common measure of treatment difference across all trials. We discuss the general applicability of this approach.

Keywords

This publication has 14 references indexed in Scilit:

A general parametric approach to the meta‐analysis of randomized clinical trials
Statistics in Medicine, 1991
An overview of statistical issues and methods of meta-analysis
Journal of Biopharmaceutical Statistics, 1991
PROPHYLACTIC USE OF 15(S)15 METHYL PGF_2α, BY INTRAMUSCULAR ROUTE — A CONTROLLED CLINICAL TRIAL
Acta Obstetricia et Gynecologica Scandinavica, 1988
BLOOD PRESSURE CHANGES WHEN UTERINE STIMULANTS ARE USED AFTER NORMAL DELIVERY
BJOG: An International Journal of Obstetrics and Gynaecology, 1979
The effect of prostaglandin F2∝ on third stage labor
Prostaglandins, 1979
A COMPARISON OF CENTRAL VENOUS PRESSURE CHANGES IN THE THIRD STAGE OF LABOUR FOLLOWING OXYTOCIC DRUGS AND DIAZEPAM
BJOG: An International Journal of Obstetrics and Gynaecology, 1974
The Obstetrician Bids, and the Uterus Contracts
BMJ, 1964
Oxytocic Drugs in Fourth Stage of Labor
JAMA, 1964
Comparative clinical evaluation of postpartum oxytocics
American Journal of Obstetrics and Gynecology, 1957
THE USE OF INTRAMUSCULAR ERGOMETRINE AT THE END OF THE SECOND STAGE OF NORMAL LABOUR
BJOG: An International Journal of Obstetrics and Gynaecology, 1951