Synthesis of 12-fluoro-corticosteroids
- 1 January 1973
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- Vol. 20, 2365-2370
- https://doi.org/10.1039/p19730002365
Abstract
Methods for the preparation of various 11 (12)-enol derivatives of steroidal 9α-fluoro-11-ketones are described. The reaction of metal enolates with perchloryl fluorides provides a convenient route to α-fluoro-ketones. Factors permitting control of the direction of enolisation of steroidal 11-ketones are defined. The synthesis of 12α- and 12β-monofluoro- and 12,12-difluoro-9α-fluoro-corticoids is reported.Keywords
This publication has 0 references indexed in Scilit: