A Controlled Trial of Amoxycillin with Clavulanic Acid (BRL 25000) against Doxycycline in Chronic Bronchitis

Open Access
Publisher Website
Google Scholar
Abstract
Thirty patients with acute exacerbations of chronic obstructive bronchitis were treated sequentially with 10-day courses of BRL 25000 (750 mg t.i.d.) and doxycycline (200 mg on Day 1, then 100 mg daily) in alternating order. BRL 25000 is a formulation of amoxycillin 500 mg with clavulanic acid 250 mg, a β-lactamase inhibitor which protects amoxycillin from destruction by these enzymes. BRL 25000 gave clinical results which compared favourably with those of doxycycline and should prove a useful antibiotic for patients with chronic obstructive bronchitis, especially against infections due to problem organisms.