Sex determination in Drosophila melanogaster: analysis of transformer-2, a sex-transforming locus.
Open Access
- 1 March 1982
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 79 (5) , 1568-1572
- https://doi.org/10.1073/pnas.79.5.1568
Abstract
The transformer-2 (tra-2) locus is one of a set of regulatory loci that control sex determination in D. melanogaster. Temperature-shift experiments with temperature-sensitive tra-2 mutants demonstrate that within single cell lineages tra-2+ function is required at several times, and probably continuously, during development for the occurrence of a series of determinative decisions necessary for female sexual differentiation. Analysis of the effects of tra-2 in the genital disc demonstrates that the tra-2+ function is necessary in females both to prevent male sexual differentiation and to permit female differentiation. The tra-2+ and tra+ loci apparently act to control the expression of the bifunctional doublesex (dsx) locus.This publication has 14 references indexed in Scilit:
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