Effect of Controlled Hydrogen-Ion Concentration on Peripheral Vascular Tone and Blood Flow in Innervated Hind Leg of the Dog

Publisher Website
Google Scholar
Abstract
The pH of the blood is progressively altered in either direction from 7.4 by intra-arterial injns. of buffered soln. of various H-ion concns., while measuring the rate of flow and the lateral pressure in the femoral artery of the normally innervated hind leg of the dog. When solns. are injd. which appreciably alter the pH of the blood in either direction from pH 7.4, increase in the rate of blood flow results. Injns. of a buffered chemical agent whose pH is on the alkaline side of the physiologic range results in a greater increase in blood flow than injns. of a buffered chemical agent whose pH is on the acid side of physiologic range by an equivalent amt. The increase in flow resulting from intra-arterial Na-pentobarbital injns., and perhaps from other buffered solns. which exhibit vasodilator properties and whose pH deviates appreciably from physiologic range, may be due in large part to the pH of the soln. Chemical agents injd. into the blood stream should be evaluated for any changes which they may induce in the blood pH.