As more and more observations are recorded on the clinical syndromes of acute disseminated lupus erythematosus and atypical verrucous endocarditis, it becomes more apparent that they constitute slightly varying but confusing manifestations of the same disease. These observations include the erythema group of cutaneous diseases with visceral manifestations first clearly pointed out by Osier1in 1904; the atypical verrucous endocarditis recognized by Libman in 1911 and reported more fully by Libman and Sacks2in 1924; the polyserositis, polyarthritis and glomerulonephritis with long-continued fever described by Christian3; a diffuse disease of the peripheral circulation usually associated with lupus erythematosus and endocarditis, reported by Baehr and associates4in 1935; the nonbacterial thrombotic endocarditis accompanied by prolonged fever, arthritis, inflammation of serous membranes and widespread vascular lesions described by Friedberg, Gross and Wallach5in 1936, and the generalized capillary and arteriolar thrombosis described by Gitlow and Goldmark6in 1939. The