Analgesic and toxic effects of ABT-594 resemble epibatidine and nicotine in rats
- 1 April 2000
- journal article
- research article
- Published by Wolters Kluwer Health in Pain
- Vol. 85 (3) , 443-450
- https://doi.org/10.1016/s0304-3959(99)00303-6
Abstract
The present study directly compared the antinociceptive and toxic effects of the neuronal nicotinic receptor agonist ABT-594 ((R)-5-(2-azetidinylmethoxy)-2-chloropyridine) with (−)-nicotine and (+)-epibatidine. Like (−)-nicotine (0.8 and 1.6 mg/kg s.c.) and (+)-epibatidine (0.005 and 0.01 mgKeywords
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