Argonaute Journeys into the Heart of RISC
- 3 September 2004
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 305 (5689) , 1409-1410
- https://doi.org/10.1126/science.1103076
Abstract
Identifying the "slicer" component of the RNA-induced silencing complex (RISC) complex has been a major goal of those interested in the RNA interference pathway of gene silencing. In their Perspective, Sontheimer and Carthew discuss a pair of recent studies ( Liu et al., Song et al.) that identify the protein Argonaute2 as the slicer element of RISC that cleaves target messenger RNAs.Keywords
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