Brain Injury in the Premature Infant – Current Concepts of Pathogenesis and Prevention

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Abstract
Brain injury in the premature infant and, particularly, the prevention of that injury is an enormous problem. With modern neonatal intensive care, approximately 85% of very low birth weight infants survive, and of these survivals, approximately 5–15 % exhibit major spastic motor deficit, grouped under the rubric, ‘cerebral palsy’, and an additional 25–50% exhibit less prominent developmental disabilities, particularly school failure.

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