Malignant Mesothelioma

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Abstract
DURING the two decades since the association of asbestos and mesothelioma became established, substantial progress has been made in the under-standing of the biology of this previously rare neoplasm. The causative role of asbestos exposure has been extensively investigated, and populations at increased risk have been identified.1 Observation of the natural history of mesothelioma reveals that in contrast to patients with the other sarcomas, who generally die of hematogenously disseminated metastases, patients with mesothelioma succumb to complications of their primary lesions.2 With more appropriate treatment regimens designed specifically for mesotheliomas, series in single institutions have established that mesotheliomas respond to . . .