Age-dependent fatty acid composition of erythrocyte membrane phospholipids in healthy children
- 1 December 1990
- journal article
- Published by Springer Nature in Zeitschrift Fur Ernahrungswissenschaft
- Vol. 29 (4) , 284-294
- https://doi.org/10.1007/bf02023085
Abstract
The fatty-acid composition of red-cell-membrane phospholipids (total phospholipids, phosphatidylcholine, and phosphatidylethanolamine fractions) was determined in 88 apparently healthy children aged 1 to 15 years, 10 cord blood samples, and 6 infants below 1 year of age. The major aim of the study was to determine the normal ranges of fatty-acid proportions, including trans- and odd-numbered fatty acids, for further studies of nutritional and metabolic disorders. The concentrations of most fatty acids of the phospholipids analyzed increased or decreased after birth and assumed adult levels before the second year of life. α-linolenic acid (C18∶3n-3) and trans fatty acids, however, continued to increase with age until late childhood. Bei insgesamt 88 gesunden Kindern im Alter zwischen 1 und 15 Jahren, 6 Kindern unter einem Jahr und in 10 Nabelschnurblutproben wurde die Fettsäurenzusammensetzung der Phospholipide (Gesamt-Phospholipide, Phosphatidylethanolamin, Phosphatidylcholin) untersucht. Ziel der Arbeit war es, altersabhängige Normbereiche für die prozentuale Fettsäurenverteilung einschlie\lich der Trans-Fettsäuren und der ungeradzahligen Fettsäuren zu erstellen, als Grundlage für weitere Untersuchungen bei Ernährungsstörungen und Stoffwechselkrankheiten. Die untersuchten Phospholipide wiesen besonders im 1. Lebensjahr deutliche Veränderungen in der Fettsäurenverteilung auf. Bis zu Beginn des 2. Lebensjahres bildete sich ein „adultes“ Muster heraus. Lediglich die prozentualen Anteile der α-Linolensäure (18∶3n-3) und die der Trans-Fettsäuren stiegen weiter bis zur zweiten Lebensdekade an.Keywords
This publication has 20 references indexed in Scilit:
- Effect of fish oil supplementation on erythrocyte lipid pattern, malondialdehyde production and glutathione-peroxidase activity in psoriasisClinica Chimica Acta; International Journal of Clinical Chemistry, 1989
- Trans fatty acid content of selected brands of West German nut-nougat creamZeitschrift Fur Ernahrungswissenschaft, 1988
- Analysis of the fatty acid composition of erythrocyte phospholipids by a base catalysed transesterification method — prevention of formation of dimethylacetalsClinica Chimica Acta; International Journal of Clinical Chemistry, 1988
- Effects of Dietary Nucleotides on the Fatty Acid Composition of Erythrocyte Membrane Lipids in Term InfantsJournal of Pediatric Gastroenterology and Nutrition, 1987
- Linoleic and trans-unsaturated fatty acid contents of adipose tissue biopsies as objective indicators of the dietary habits of individualsProgress in Lipid Research, 1986
- Fatty Acid Pattern of the Erythrocyte Lipids and Plasma Vitamin E in the First Days of LifeNeonatology, 1981
- Altered phospholipid composition and changed fatty acid pattern of the various phospholipid fractions of red cell membranes of cystic fibrosis children with pancreatic insufficiencyClinica Chimica Acta; International Journal of Clinical Chemistry, 1980
- Gas chromatographic determination of the fatty acid pattern of red cell membrane plasmalogens in healthy childrenJournal of Chromatography B: Biomedical Sciences and Applications, 1980
- Transfer of phospholipids between membraneBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1974
- FATTY ACID COMPOSITION OF PLASMA AND RED CELL PHOSPHOGLYCERIDES IN FULL TERM INFANTS AND THEIR MOTHERS1Acta Paediatrica, 1970