Autoradiographic Studies on Histogenesis of Brain Macrophages in the Mouse

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Abstract
Adult mice of the dd strain were repeatedly injected with tritiated thymidine to label (a high percentage of circulating monocytes. Subsequently, five of them received stab wounds in the cerebral cortex made with a heated needle and were sacrificed by perfusion fixation from 6 to 74 hours after the time of injury. Labeled and unlabeled cells appearing in the neighborhood of the wound were examined by light and electron microscopic autoradiography, and their relationship to blood monocytes and perivascular cells was studied. The following results were obtained.