T lymphocytes in peripheral blood from patients with neurological diseases

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Abstract
Absolute and relative numbers of T [thymus-derived] lymphocytes in peripheral blood were determined in 19 different groups of patients with neurological diseases, using the E[erythrocyte]-rosette test. A significantly decreased total number of T lymphocytes was found in the following groups: acute Guillain-Barre syndrome (GBS), active multiple sclerosis (MS), and malignant cerebral tumor. A less pronounced and insignificant reduction was observed in patients with amyotrophic lateral sclerosis (ALS). In all other groups of patients normal total numbers of T lymphocytes were found, indicating that the decrease in T lymphocyte counts in GBS, MS and malignant cerebral tumors is not due to nonspecific injury of nerve tissue.