Abstract
Phenylbutazone, sodium salicylate, calcium acetylsalicylate and sodium mefenamate each antagonize the bradykinin-induced increase of capillary permeability in the rat paw. The method described was not affected to any extent by urethane anaesthesia nor by mecamylamine, papaverine, reserpine or chlorothiazide. Hexobarbitone partially inhibited the bradykinin effect, as did bretylium and acetic acid.