Adenosine Blocks Calcium Entry in Activated Neutrophils and Binds to Flunarizine-Sensitive Calcium Channels

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Abstract
Adenosine is able to prevent Ca++ influx into activated neutrophils as detected by the specific fluorescent indicator Quin 2. Such an effect is shown in a similar fashion by the calcium entry blocker flunarizine. The binding interaction between flunarizine and the neutrophil membrane as well as the flunarizine-adenosine antagonism are shown by the 1H-NMR technique, thus supporting evidence of a competition between the agents at the same or a nearby site on the cell membrane.