The particle size evaluation of parenteral suspensions of chloramphenicol and correlation of particle size to plasma levels.

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Abstract
The method of particle size evaluation of chloramphenicol suspensions with the Coulter counter was studied. Using the salt solution, which was supersaturated with chloramphenicol and contained a small amount of polyvinylpyrrolidone to attain a wide range of supersaturation of chloramphenicol, as a diluent, the particle size analysis of chloramphenicol suspensions can be made reproducibly in the size range from 0.7-2.0 .mu.. Chloramphenicol suspensions containing different average size particles were administered i.m. to rabbits and the peak plasma levels obtained were directly related to the reciprocals of the average particle diameters measured by this method.

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