Gene therapy for HIV infection: what does it need to make it work?
- 6 April 2006
- journal article
- review article
- Published by Wiley in The Journal of Gene Medicine
- Vol. 8 (6) , 658-667
- https://doi.org/10.1002/jgm.908
Abstract
The efficacy of antiviral drug therapy for HIV infection is limited by toxicity and viral resistance. Thus, alternative therapies need to be explored. Several gene therapeutic strategies for HIV infection have been developed, but in clinical testing therapeutically effective levels of the transgene product were not achieved. This review focuses on the determinants of therapeutic efficacy and discusses the potential and also the limits of current gene therapy approaches for HIV infection. Copyright © 2006 John Wiley & Sons, Ltd.Keywords
This publication has 93 references indexed in Scilit:
- Approach to the Treatment-experienced patientCurrent HIV/AIDS Reports, 2005
- Gene therapy progress and prospects: Novel gene therapy approaches for AIDSGene Therapy, 2005
- A Phase II Randomized Study of HIV-Specific T-Cell Gene Therapy in Subjects with Undetectable Plasma Viremia on Combination Antiretroviral TherapyMolecular Therapy, 2002
- HIV preferentially infects HIV-specific CD4+ T cellsNature, 2002
- Prolonged survival and tissue trafficking following adoptive transfer of CD4ζ gene-modified autologous CD4+ and CD8+ T cells in human immunodeficiency virus–infected subjectsBlood, 2000
- Retrovirally Mediated IFN-β Transduction of Macrophages Induces Resistance to HIV, Correlated with Up-Regulation of RANTES Production and Down-Regulation of C-C Chemokine Receptor-5 ExpressionThe Journal of Immunology, 2000
- Killing HIV-infected cells by transduction with an HIV protease-activated caspase-3 proteinNature Medicine, 1999
- Gene therapy of T helper cells in HIV infection: Mathematical model of the criteria for clinical effectBulletin of Mathematical Biology, 1997
- Expression of a Tat-inducible herpes simplex virus-thymidine kinase gene protectsacyclovir-treated CD4 cells from HIV-1 spread by conditional suicide and inhibition of reverse transcriptionVirology, 1995
- Intracellular immunizationNature, 1988