Acute Degenerative Changes in Adenomas of the Pituitary Body—with Special Reference to Pituitary Apoplexy

Abstract
5 cases of pituitary adenoma showed the unique feature of hemorrhage into and/or extensive necrosis of the adenoma with the sudden onset of drowsiness, stupor or coma, headache and stiff neck, ocular palsies and sometimes amblyopia or hemlparesis. The acute retrogressive changes are thought to be due to an excessively rapid growth of some pituitary adenomas. The necessity of differentiation from crises of adrenal insufficiency, a temporal lobe pressure cone and convulsive states is dlscussed.

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