EXPERIMENTAL STUDY OF BONE REPAIR

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Abstract
The observed relationship of the parathyroid glands to calcium and phosphorus metabolism and of vitamin D to rickets and osteomalacia and the possible interrelationship between the parathyroid glands and vitamin D have served as the stimulus for a great amount of experimental and clinical investigation of the factors that govern or may influence bone growth and bone repair after injury. In addition to the question of analyzing the causes that may operate to delay union or bone repair, there is the question of the possibility of accelerated repair, which can be more intelligently approached as the physiologic mechanisms of ossification become better understood. In the older literature there are several reports that the partial or complete absence of the parathyroids causes a lessened deposition of calcium in the osteoid tissues during periods of growth or repair; for example, that in growing rats and dogs after partial parathyroidectomy the deposit of