Asymmetric alkylation of a chiral α-amino alkenenitrile
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 22,p. 1787-1788
- https://doi.org/10.1039/c39890001787
Abstract
Alkylation of the unsymmetric allylic anion generated from 2-(L-ephedrino)-4-phenylbut-3-enenitrile occured exclusively at C-4 to give predominantly products having the 4R-configuration; the stereoselectivity increased remarkably when the reaction was conducted in a mixture of hexamethylphosphoramide and lithium iodide.Keywords
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