The unusual combination of progressive growth resulting in gigantism and mild acromegaly, of muscular atrophy of the extremities and trunk on one side of the body resulting in hemiparesis and associated with creatinuria and absence of reaction of degeneration, of mild hypersomnia and of diabetes insipidus which was controlled by the administration of solution of pituitary is the reason for reporting the following case. It is our belief that all of these manifestations have their origin in the cerebral visceral parts of the central nervous system which control the physicochemical activities of the body and are located in or about the floor of the third ventricle. Recently, renewed interest has been taken in this portion of the nervous system, and evidence has accumulated to show that the cell groups lying about the tuber cinereum play an important part in regulating the sleep cycle, temperature, the metabolism of fats, sugar, salt