Natural and Synthetic Inhibitors of Choline Esterase

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Abstract
Studies of the action of indole, N-methyl indole and oxidation products of adrenaline on choline esterase in human scrum gave the following results: indole[long dash]50% inhibition in a molar conc. of 10-2 as compared with 50% inhibition by phy-sostigmine in H 10-6 molar cones. N-methyl indole was twice as effective as indole. Oxidation products of adrenaline differed in action depending on the type of oxidation and pH at which oxidation occurred. The least active sample of adrenaline showed 50% inhibition in molar conc. of 2.5 X 10-3.