Locomotor activity stimulation in rats produced by dopamine in the nucleus accumbens: potentiation by caffeine
- 1 September 1975
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 27 (9) , 666-670
- https://doi.org/10.1111/j.2042-7158.1975.tb09529.x
Abstract
The increased motor activity of reserpine-nialamide pretreated rats given dopamine into the nucleus accumbens was potentiated in a dose-dependent manner by systemically administered caffeine. Similarly, the increase in motor activity seen when the endogenous dopamine was released by intraperitoneally administered amphetamine was potentiated by systemically given caffeine. These effects might be due to an increase in the dopamine-induced accumulation of cyclic AMP in the nucleus accumbens after inhibition of the phosphodiesterase by caffeine.Keywords
This publication has 9 references indexed in Scilit:
- DOPAMINE IN THE MESOLIMBIC SYSTEM OF THE RAT BRAIN: ENDOGENOUS LEVELS AND THE EFFECTS OF DRUGS ON THE UPTAKE MECHANISM AND STIMULATION OF ADENYLATE CYCLASE ACTIVITYJournal of Neurochemistry, 1974
- Stimulation of locomotor activity following injection of dopamine into the nucleus accumbensJournal of Pharmacy and Pharmacology, 1973
- Behavioural and biochemical interaction between caffeine and l-dopaJournal of Pharmacy and Pharmacology, 1973
- Sensitization by caffeine of central catecholamine receptorsJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1973
- Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the “dopamine receptor”Proceedings of the National Academy of Sciences, 1972
- Effects of Caffeine and Theophylline on Activity of Rats in Relation to Brain Xanthine ConcentrationsExperimental Biology and Medicine, 1972
- An investigation of a new instrument to measure motor activity of small animalsPsychopharmacology, 1969
- Vergleichende Untersuchungen ber zentrale Wirkungen von Xanthinderivaten in Hinblick auf deren Stoffwechsel und Verteilung im OrganismusNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1968
- Functional Role of the Nigro‐Neostriatal Dopamine Neurons*)Acta Pharmacologica et Toxicologica, 1966