Anti-idiotypes to monoclonal anti-H-2 antibodies. III. Syngeneic anti-idiotypes on antibodies induced by in vivo administration of xenogeneic anti-idiotypes.
Open Access
- 1 November 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 129 (5) , 2066-2068
- https://doi.org/10.4049/jimmunol.129.5.2066
Abstract
Idiotype-positive molecules induced by xenogeneic anti-idiotypes (anti-Id) to monoclonal anti-H-2 antibodies were studied using syngeneic anti-Id reagents. Syngeneic reagents detected idiotypes on both H-2 antigen-binding and nonbinding Id' induced by xenogeneic anti-Id. In addition, idiotopes were readily detected by alloimmunization after xenogeneic anti-Id reagents interact with some of the same antibodies as syngeneic anti-Id and support the hypothesis that treatment with xenogeneic anti-Id may affect a physiologically important idiotypic network.This publication has 3 references indexed in Scilit:
- Anti-idiotypes to monoclonal anti-H-2 antibodies. II. Expression of anti-H-2Kk idiotypes on antibodies induced by anti-idiotype or H-2Kk antigen.The Journal of Experimental Medicine, 1981
- Idiotypes of anti-Ia antibodies. I. Expression of the 14-4-4S idiotype in humoral immune responses.The Journal of Experimental Medicine, 1981
- Induction of anti-H–2 antibodies without alloantigen exposure by in vivo administration of anti-idiotypeNature, 1981