Effect of diclofenac on prostaglandin E and hyaluronic acid production by human synovial fibroblasts stimulated with interleukin‐1.
- 1 August 1989
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 28 (2) , 193-196
- https://doi.org/10.1111/j.1365-2125.1989.tb05416.x
Abstract
Cultured human synovial fibroblasts were stimulated with human recombinant interleukin 1 beta to overproduce prostaglandin E (PGE) and hyaluronic acid (HA). Diclofenac, indomethacin and hydrocortisone inhibited stimulation of PGE production. Half‐maximal inhibition occurred at 1.10 x 10(‐9), 2.79 x 10(‐8) and at 5.52 x 10(‐8) M, respectively. Diclofenac or indomethacin had no effect on HA production, while hydrocortisone had an inhibitory effect (half‐maximal inhibition at 2.76 x 10(‐7) M). This model could be a useful in vitro indicator for the in vivo pharmacological actions of anti‐inflammatory drugs.This publication has 7 references indexed in Scilit:
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