Expression of the FGFR1 gene in human breast‐carcinoma cells

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Abstract
Fibroblast growth factors (FGF) constitute a family of at least 9 members which act through high‐affinity tyrosine‐kinase receptors encoded by 4 distinct genes. In humans, the FGFRI gene is located in chromosomal region 8pl2. Its amplification and expression were examined in a panel of 110 breast carcinoma samples by Southern‐ and Northern‐blot analyses. FGFRI was amplified in 9% and overexpressed in about 15% of the tumors studied. In situ hybridization experiments were performed on tissue sections of normal breast and tumors with a high level of FGFRI expression. In both normal and tumoral tissues, FGFRI RNA was detected in the epithelial cells. Overexpression of FGFRI seems to be associated with small, well‐differentiated diploid tumors.