Synthesis of guinea-pig cardiac myosin as measured by constant infusion
- 15 January 1978
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 170 (1) , 189-192
- https://doi.org/10.1042/bj1700189
Abstract
An equation was derived from which the turnover time of individual muscle proteins could be calculated from measurements made at a single time interval in individual animals after initiation of constant intravenous infusion of labelled amino acid. The calculation requires only the specific radioactivities of the amino acid in plasma, in the intracellular fluid and in the protein under study. Pool sizes were not required. When the equation was applied to adult guinea-pig cardiac myosin, the average turnover time was 16 +/- 1 days.This publication has 23 references indexed in Scilit:
- Skeletal-muscle growth and protein turnoverBiochemical Journal, 1975
- The specific radioactivity of the precursor pool for estimates of the rate of protein synthesis (Short Communication)Biochemical Journal, 1973
- Protein synthesis and turnover in normal and hypertrophied heartThe American Journal of Cardiology, 1973
- The rate of incorporation of amino acids into brain proteins during infusion in the ratBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973
- Effect of l-thyroxine on the primary structure of cardiac myosinBiochimica et Biophysica Acta (BBA) - Bioenergetics, 1970
- Analysis of a five-compartment system with continuous infusion and its application to the study of amino acid turnoverJournal of Theoretical Biology, 1970
- Effect of age on protein and ribonucleic acid metabolism in mouse skeletal muscleCanadian Journal of Biochemistry, 1969
- Origins and metabolism of the intracellular amino acid pools in rat liver and muscleBiochimica et Biophysica Acta (BBA) - General Subjects, 1967
- Molecular Characteristics of Canine Cardiac MyosinCirculation Research, 1965
- The design and analysis of isotope experimentsThe American Journal of Medicine, 1960