Structural Changes in Aging Serum I.

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Abstract
Structures, on the average 300 [mu] in size, resembling colonies of bacteria, fungi and actinomycetes were found on sterile bacteriological agar plates containing filtered serum, after long-term incubation at 37[degree]C. It was demonstrated that these structures are not a change agglomeration of precipitate and that they originate in serum, in the presence of dead cells, and that their formationin induced by some material which is present in cell nuclei. Their growth can be elicited on serum agar by material percipitated in serum incubated at 37[degree]C for several weeks. The form of the structures is specific for different animal species and may serve to identify the source of the oerum sampled. Staining disclosed that the structures are composed of 2 different substances of which only 1 takes up fat-soluble dyes. The structures can be stained with hematoxylin and eosin or light green. The reaction of polysaccharides is positive.

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