Plasmatic and Platelet Anti-Plasmins and Anti-Activators

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Abstract
Direct antiplasmin and anti-urokinase can be measured with artificial clots to which plasma, serum or platelet suspension is added incubated in plasmin or urokinase respectively. Whilst only 3% of the total antiplasmin in the blood is present in the platelets, there is 40% of the total antiurokinase present in the platelets. The properties of this thrombocytic anti-urokinase are discussed. Only 60% is soluble in water. By heating this solution the inhibiting effect increases. Platelet anti-activator is also active against other activators but has not the same properties as anti-urokinase. Implications of these findings are discussed.
Funding Information
  • Netherlands Organisation for pure scientific research

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