THE SECRETION OF AMMONIA BY THE SMALL INTESTINE OF THE DOG

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Abstract
The ammonia content in the succus entericus from a Thiry-Vella loop of jejunum in the dog was decreased by a carbohydrate diet; increased by a meat diet, by intraven. inj. of glycine or alanine (42-164% increase) and by urea (increase partially checked by the intrav. inj. of NaCl). The protein diets probably did not increase the juice ammonia by elevating blood urea because extensive diuresis prevented the elevation of blood urea without interfering with the dietary effect upon the ammonia content. The inj. of insulin increased juice ammonia in 12 of 15 expts.; adrenalin inj. decreased it in 12 expts. and increased it in 14. The ammonia secreted by the glands of the jejunum and its conc. in the juice was apparently dependent upon the protein metabolism in the glands.

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