Comparison of cefadroxil and cephalexin therapies in the treatment of acute lower respiratory tract infections in children

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Abstract
Fifty children between 1 and 12 years of age, diagnosed as having clinical pneumonia, broncho-pneumonia, or bronchitis, participated in this single-blinded parallel group study with randomized drug assignment. Each patient received 10 days of drug therapy weith pre-, interim, and post-study visits for clinical and laboratory evaluation. Forty-six of the 50 patients completed the study and were cured. Two patients receiving cefadroxil had unresponsive infections, and required ampicillin/amoxycillin. Two patients receiving cephalexin were removed from the study; one for non compliance and one because of an allergic rash requiring cessation of the study drug. Cefadroxil, administered twice daily at a total dose of 30 mg/kg/day, was shown to be (1) safe and effective in treating lower respiratory tract infections in children and (2) as effective as cephalexin administered four times daily at a total dose of 50 mg/kg/day. Clinical response to cefadroxil was not altered by food ingestion.

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