Live Attenuated Rubella Virus Vaccines Prepared in Duck Embryo Cell Culture

Publisher Website
Google Scholar
Abstract
Merck strain rubella virus and Meyer-Parkman monkey kidney attenuated HPV-77 virus were prepared at various levels of attenuation for investigative use in humans and animals. The vaccines were produced in duck embryo cell culture and represented a spectrum which ranged from underattenuation, causing communicable mild rubella, to overattenuation with apparent nonexcretion and inadequate immunization. Merck strain rubella virus at attenuation level B, or possibly C, and Meyer-Parkman HPV-77 virus in fifth passage in duck embryo cell culture appear to present the attributes of an effective noncontagious vaccine. The antibody, produced in children after administration of level C vaccine, persisted undiminished for at least one year. Duck embryo cell culture appeared to be an attractive material for preparing vaccine because it was of a nonmammalian source and because of the relative freedom of ducks from disease.

This publication has 0 references indexed in Scilit: