The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism*†
Top Cited Papers
- 1 January 2001
- journal article
- review article
- Published by Taylor & Francis in Drug Metabolism Reviews
- Vol. 33 (3-4) , 273-297
- https://doi.org/10.1081/dmr-120000653
Abstract
At present, the methods and enzymology of the UDP-glucuronosyltransferases (UGTs) lag behind that of the cytochromes P450 (CYPs). About 15 human UGTs have been identified, and knowledge about their...Keywords
This publication has 56 references indexed in Scilit:
- Roles of glucuronidation and UDP-glucuronosyltransferases in xenobiotic bioactivation reactionsChemico-Biological Interactions, 2000
- ADME/PK as part of a rational approach to drug discoveryDrug Discovery Today, 2000
- Human UDP-Glucuronosyltransferases: Metabolism, Expression, and DiseaseAnnual Review of Pharmacology and Toxicology, 2000
- STRUCTURAL AND FUNCTIONAL STUDIES OF UDP-GLUCURONOSYLTRANSFERASES*Drug Metabolism Reviews, 1999
- Inhibitory effects of uridine diphosphate on udp-glucuronosyltransferaseLife Sciences, 1998
- STRUCTURE AND FUNCTION OF URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASESClinical and Experimental Pharmacology and Physiology, 1997
- The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergencePharmacogenetics, 1997
- Structure and Functions of Channel-Forming Peptides: Magainins, Cecropins, Melittin and AlamethicinThe Journal of Membrane Biology, 1997
- Drug glucuronidation in humansPharmacology & Therapeutics, 1991
- The competitive inhibition of p-nitrophenyl-β-d-glucopyranosiduronic acid synthesis by aliphatic alcohols in vitroBiochemical Pharmacology, 1966